1 First Department of Radiology, School of Medicine, National and Kapodistrian University of Athens , Athens , Greece.
2 Computational Clinical Imaging Group, Centre for the Unknown, Champalimaud Foundation , Lisbon , Portugal.
Br J Radiol. 2018 Jul;91(1088):20170389. doi: 10.1259/bjr.20170389. Epub 2018 Feb 13.
MRI plays an important role in the management of patients with plasma cell neoplasms and has been recognized as a biomarker of malignancy in the novel criteria for the diagnosis of multiple myeloma. Functional and molecular MRI techniques such as diffusion-weighted imaging (spinal or whole body), intravoxel incoherent motion, and dynamic contrast enhanced MRI, provide additional information related to tumor cellularity and angiogenesis, which may have prognostic implications for patients with smoldering and symptomatic myeloma. These non-invasive functional techniques are also being evaluated as imaging biomarkers for response assessment in myeloma patients. The purpose of this article is to provide a comprehensive critical review on the current use and potential future applications of these advanced MRI techniques in multiple myeloma. In addition, we will address the technologies involved and describe the qualitative and quantitative characteristics of normal bone marrow with these techniques.
MRI 在浆细胞肿瘤患者的管理中发挥着重要作用，并且已被认为是新的多发性骨髓瘤诊断标准中恶性肿瘤的生物标志物。功能和分子 MRI 技术，如弥散加权成像（脊柱或全身）、体素内不相干运动和动态对比增强 MRI，提供了与肿瘤细胞密度和血管生成相关的额外信息，这可能对冒烟型和有症状骨髓瘤患者具有预后意义。这些非侵入性的功能技术也正在作为骨髓瘤患者反应评估的影像学生物标志物进行评估。本文的目的是对这些先进的 MRI 技术在多发性骨髓瘤中的当前应用和潜在的未来应用进行全面的批判性综述。此外，我们将讨论涉及的技术，并描述这些技术对正常骨髓的定性和定量特征。
