Hinton R C, Kistler J P, Fallon J T, Friedlich A L, Fisher C M
Am J Cardiol. 1977 Oct;40(4):509-13. doi: 10.1016/0002-9149(77)90064-9.
Atrial fibrillation is well known to increase greatly the risk of systemic arterial embolism in patients with mitral valve disease. In light of the clinical frequency of embolism in patients with atrial fibrillation due to other types of heart disease, a study was made of embolic occurrences in 333 autopsy patients with atrial fibrillation associated with various kinds of heart disease. Considering only symptomatic emboli with pathologic or surgical confirmation, embolism occurred in 41% of patients with mitral valve disease, 35% of those with ischemic heart disease, 35% of those with coexisting mitral and ischemic heart disease and 17% of those with "other" types of heart disease. Embolism was found in only 7% of a control group of 58 autopsy patients with ischemic heart disease without atrial fibrillation. These findings suggest a high risk of embolism from atrial fibrillation of any origin, but particularly from that caused by ischemic heart disease and mitral valve disease.
众所周知，心房颤动会大大增加二尖瓣疾病患者发生系统性动脉栓塞的风险。鉴于其他类型心脏病所致心房颤动患者发生栓塞的临床频率，对333例伴有各种心脏病的心房颤动尸检患者的栓塞情况进行了研究。仅考虑经病理或手术证实的有症状栓塞，二尖瓣疾病患者中41%发生栓塞，缺血性心脏病患者中35%发生栓塞，并存二尖瓣和缺血性心脏病患者中35%发生栓塞，“其他”类型心脏病患者中17%发生栓塞。在58例无心房颤动的缺血性心脏病尸检对照组患者中，仅7%发现有栓塞。这些发现表明，任何原因引起的心房颤动，尤其是由缺血性心脏病和二尖瓣疾病引起的心房颤动，发生栓塞的风险都很高。
