Val'vachev N I, Goren'kova V F, Zhizhel' A O
Antibiotiki. 1977 Aug;22(8):719-22.
Resistance of 2345 strains of plasmocoagulating staphylococci isolated from purulent inflammatory foci of surgical patients was studied with respect to the widely used antibiotics by the method of standard paper discs in 1970--1975. It was noted that the cultures resistant to erythromycin and monomycin were more frequent, i.e. from 24.2 +/- 2.5 to 51.4 +/- 3.4 per cent and from 1.0 +/- 0.6 to 28.0 +/- 2.1 per cent respectively, p less than 0.001 in both cases, while the percentage of the strains resistant to benzylpenicillin and tetracycline steadily increased, i.e. from 69.9 +/- 2.4 to 47.0 +/- 2.3 per cent and from 72.8 +/- 2.4 to 28.4 +/- 2.1 per cent respectively, p less than 0.001 in both cases. The number of the resistant cultures to streptomycin and levomycetin slightly changed and was relatively high (about 50 per cent and more). Direct correlation (mean and pronounced) between the amount of levomycetin, tetracycline, erythromycin or monomycin used per citizen of Minsk and the frequency of the strains isolated from the patients to these drugs was noted.
1970年至1975年期间，采用标准纸片法对从外科患者脓性炎症病灶分离出的2345株血浆凝固酶阳性葡萄球菌，就广泛使用的抗生素的耐药性进行了研究。结果发现，对红霉素和新生霉素耐药的培养物更为常见，即分别从24.2±2.5%增至51.4±3.4%以及从1.0±0.6%增至28.0±2.1%，两种情况的p值均小于0.001，而对苄青霉素和四环素耐药的菌株百分比稳步上升，即分别从69.9±2.4%降至47.0±2.3%以及从72.8±2.4%降至28.4±2.1%，两种情况的p值也均小于0.001。对链霉素和氯霉素耐药的培养物数量略有变化且相对较高（约50%及以上）。观察到明斯克市人均使用氯霉素、四环素、红霉素或新生霉素的量与从患者中分离出的对这些药物耐药菌株的频率之间存在直接相关性（中等且显著）。
