[阿米齐尔和槟榔碱对大鼠脑神经末梢摄取45钙的影响]
[Effect of amizil and arecoline on 45Ca uptake by rat brain nerve endings].
作者信息
Semenov E V
出版信息
Biull Eksp Biol Med. 1978 Sep;86(9):301-4.
The effect of benactyzine (amizyl--the central cholinolytic) and arecoline (cholinomimetic) in vitro on the 45Ca uptake by the nerve endings (synaptosomes) of the rat brain was studied. Benactyzine proved to evoke a biphasic change of the isotope uptake, whereas arecoline induced an initial rapid increase of the 45Ca uptake. Benactyzine suppressed the influence of arecoline and of depolarization on the isotope uptake. A conclusion was drawn that an increase of the 45Ca uptake under the action of arecoline was connected with activization of the Na-K canals. On the contrary, benactyzine depressed the permeability of these canals for 45Ca and activated the calcium canals proper.
研究了苯那辛（阿密替林——中枢抗胆碱药）和槟榔碱（拟胆碱药）在体外对大鼠脑神经元末梢（突触体）摄取⁴⁵Ca的影响。结果表明，苯那辛可引起同位素摄取的双相变化，而槟榔碱则使⁴⁵Ca摄取最初迅速增加。苯那辛可抑制槟榔碱和去极化对同位素摄取的影响。得出的结论是，槟榔碱作用下⁴⁵Ca摄取的增加与钠钾通道的激活有关。相反，苯那辛降低了这些通道对⁴⁵Ca的通透性，并激活了钙通道本身。
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