乙酰甲胆碱诱发的支气管收缩对哮喘患者呼吸音频谱特征的影响。
Effect of methacholine induced bronchoconstriction on the spectral characteristics of breath sounds in asthma.
作者信息
Spence D P, Bentley S, Evans D H, Morgan M D
机构信息
Department of Respiratory Medicine, Glenfield General Hospital, Leicester.
出版信息
Thorax. 1992 Sep;47(9):680-3. doi: 10.1136/thx.47.9.680.
BACKGROUND
Analysis of breath sounds by digital techniques offers an attractive non-invasive method of monitoring changes in airway calibre. Asthmatic breath sounds have been analysed and related to changes in forced expiratory volume in one second (FEV1).
METHODS
Bronchoconstriction was induced with methacholine in six asthmatic subjects on two occasions and changes in FEV1 and breath sound spectra were measured.
RESULTS
Audible wheeze appeared after a mean (SE) fall in FEV1 of 35% (6.3%) but the level was not reproducible within patients. The mean and median frequency of the spectra of breath sounds correlated with the percentage of predicted FEV1 (r = -0.5 and -0.6 respectively; p < 0.001). Inclusion of the quartile frequencies in a stepwise multiple regression reduced the residual variance by a further 9%.
CONCLUSION
Detecting changes in airway calibre by this method of sound analysis so far produces qualitative data only and will not yield quantitative data in individual patients.
背景
通过数字技术分析呼吸音提供了一种有吸引力的监测气道口径变化的非侵入性方法。哮喘患者的呼吸音已被分析，并与一秒用力呼气量（FEV1）的变化相关。
方法
对6名哮喘患者进行两次实验，用乙酰甲胆碱诱发支气管收缩，并测量FEV1和呼吸音频谱的变化。
结果
FEV1平均（标准误）下降35%（6.3%）后出现可闻及的哮鸣音，但患者个体内该水平不可重复。呼吸音频谱的平均频率和中位数频率与预测FEV1的百分比相关（分别为r = -0.5和-0.6；p < 0.001）。在逐步多元回归中纳入四分位数频率可使残差方差进一步降低9%。
结论
迄今为止，通过这种声音分析方法检测气道口径变化仅产生定性数据，无法在个体患者中得出定量数据。
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