Santoro F M, Alvarez R, Fussi F
Research Laboratories, Syntex S.A., Pcia. Buenos Aires, Argentina.
Thromb Res. 1992 Jul 15;67(2):201-11. doi: 10.1016/0049-3848(92)90139-2.
We performed different "in vivo" investigations to study the pharmacological properties of a native DS: anti-thrombosis by the stasis model, bleeding potential by tail transection bleeding time and template bleeding time, and profibrinolysis by a growing thrombus model and by an established thrombus model. The results suggest that DS is a safe antithrombotic drug by i.v. administration without bleeding potential, even at very high doses (up to 16 mg/Kg). DS has shown a protective index of at least 4 in contrast to heparin that has shown a protective index of 1. The profibrinolytic models so far studied did not evidence a clear profibrinolytic contribution to the antithrombotic properties of DS, but showed a prolonged antithrombotic action that cannot be explained only by the heparin cofactor II potentiation.
我们进行了不同的“体内”研究，以探究一种天然硫酸皮肤素（DS）的药理特性：通过瘀血模型研究其抗血栓形成作用，通过尾部横断出血时间和模板出血时间研究其出血倾向，以及通过生长血栓模型和已形成血栓模型研究其促纤溶作用。结果表明，静脉给药时，DS是一种安全的抗血栓药物，即使在非常高的剂量（高达16mg/Kg）下也没有出血倾向。与肝素的保护指数为1相比，DS的保护指数至少为4。迄今为止所研究的促纤溶模型并未证明DS的抗血栓特性有明显的促纤溶作用，但显示出其抗血栓作用延长，这不能仅通过肝素辅因子II的增强来解释。
