Kraivichian P, Kulkumthorn M, Yingyourd P, Akarabovorn P, Paireepai C C
Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Trans R Soc Trop Med Hyg. 1992 Jul-Aug;86(4):418-21. doi: 10.1016/0035-9203(92)90248-b.
The efficacy of albendazole was investigated in 112 patients with symptomatic gnathostomiasis; 49 received 400 mg twice daily, 51 received 400 mg once daily, and 12 patients received placebo, all for 21 d. Subsequent follow-up was for 6 months. Cure (no further swelling) was seen in 93.9% and 94.1% of the treatment groups but in none of the placebo group. Additionally, reductions in eosinophil counts and in immunoglobulin G antibody were observed after treatment. Side effects were minimal. Albendazole may be an effective compound for the treatment of gnathostomiasis.
在112例有症状的颚口线虫病患者中研究了阿苯达唑的疗效；49例患者每日两次服用400毫克，51例患者每日一次服用400毫克，12例患者服用安慰剂，均持续21天。随后的随访为期6个月。治疗组中分别有93.9%和94.1%的患者治愈（肿胀未再出现），但安慰剂组无一例治愈。此外，治疗后观察到嗜酸性粒细胞计数和免疫球蛋白G抗体有所下降。副作用极小。阿苯达唑可能是治疗颚口线虫病的有效药物。
