Khushbaktova Z A, Tashmukhamedova M A, Syrov V N, Mirtalipov D T, Grunina I I
Ukr Biokhim Zh (1978). 1992 May-Jun;64(3):86-91.
Peroral administration of salvipholin in a dose of 50 mg/kg to intact male rats (the body weight 180-220 g) had a positive effect on the carbohydrate-lipid metabolism in the liver and blood serum of animals. Administration of the same dose to rats with alloxan diabetes induced a significant decrease in the content of glucose, free fat acids, triglycerides and lysophospholipids of the liver and blood serum. The level of these components has sharply increased after subcutaneous alloxan administration in a dose of 150 mg/kg, the content of glycogen and pyruvic acid being normalized and insulin deficiency removed. These changes are closely related to salvipholin-promoted restoration of phospholipid spectra of the blood serum and liver of experimental animals disturbed under conditions of insulin deficiency. The possible mechanism of the salvipholin action is analyzed.
给体重180 - 220克的健康雄性大鼠口服50毫克/千克的丹参酚酸，对动物肝脏和血清中的碳水化合物 - 脂质代谢有积极作用。给四氧嘧啶糖尿病大鼠施用相同剂量后，肝脏和血清中的葡萄糖、游离脂肪酸、甘油三酯和溶血磷脂含量显著降低。以150毫克/千克的剂量皮下注射四氧嘧啶后，这些成分的水平急剧上升，糖原和丙酮酸含量恢复正常，胰岛素缺乏得到消除。这些变化与丹参酚酸促进实验动物在胰岛素缺乏条件下紊乱的血清和肝脏磷脂谱的恢复密切相关。分析了丹参酚酸作用的可能机制。
