Syrov V N, Tashmukhamedova M A, Khushbaktova Z A, Mirtalipov D T, Mamatkhanov A U
Ukr Biokhim Zh (1978). 1992 Jul-Aug;64(4):61-7.
Phytoecdysteroids: ecdysterone and turkesterone, introduced orally to male rats with the body mass 180-120 g in a dose of 5 mg/l kg of mass and nerobol in a dose of 10 mg per 1 kg of the mass for 15 days against a background of the developed alloxan diabetes cause a considerable decrease in the content of free fatty acids of the blood serum, sharply increased after the subcutaneous injection of alloxan to the animals (150 mg per 1 kg of the mass). The content of glycogen, malonic dialdehyde, pyruvic acid and calcium transporting function of the liver mitochondria are also normalized. These changes are closely interrelated (and may be mutually conditioned) with the preparation-induced reduction of phospholipid spectrum of the liver mitochondrial membranes pathologically changed owing to insulin insufficiency. In this case phytoecdysteroids in the first turn normalize the fractions of phospholipids which play the structural role in the mitochondrial membranes, and nerobol normalizes the level of minor and monoacylic phospholipids.
蜕皮激素和土克甾酮，以5毫克/千克体重的剂量口服给予体重为180 - 120克的雄性大鼠，以10毫克/千克体重的剂量给予神经甾醇，持续15天，在已诱发四氧嘧啶糖尿病的背景下，可使血清游离脂肪酸含量显著降低，该含量在给动物皮下注射四氧嘧啶（150毫克/千克体重）后急剧升高。肝糖原、丙二醛、丙酮酸的含量以及肝线粒体的钙转运功能也恢复正常。这些变化与制剂诱导的因胰岛素不足而发生病理改变的肝线粒体膜磷脂谱的降低密切相关（且可能相互制约）。在这种情况下，植物蜕皮甾类首先使在线粒体膜中起结构作用的磷脂组分恢复正常，而神经甾醇则使次要和单酰基磷脂的水平恢复正常。
