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鸟类肝脏中脂肪酸和胆固醇合成调控的研究。

Studies on the regulation of fatty acid and cholesterol synthesis in avian liver.

作者信息

LAYNE E C, RUDOLPH G G, BESSMAN S P

出版信息

Science. 1960 Aug 12;132(3424):418-9. doi: 10.1126/science.132.3424.418.

DOI:10.1126/science.132.3424.418
PMID:14414775
Abstract

Homogenates of pigeon liver have been incubated with acetate-C(14) in excess. Simultaneously, substrate for glycolysis was provided as glucose-6-phosphate. The incorporation of carbon-14 into cholesterol was maximal at low levels of glycolysis, whereas fatty acid turnover was maximum at higher glycolytic levels. A regulatory mechanism is proposed to explain the differential synthesis of cholesterol and fatty acids.

摘要

已将过量的乙酸 - C(14) 与鸽肝匀浆一起孵育。同时，提供磷酸葡萄糖作为糖酵解的底物。在糖酵解水平较低时，碳 - 14 掺入胆固醇的量最大，而在较高糖酵解水平时，脂肪酸周转量最大。提出了一种调节机制来解释胆固醇和脂肪酸的差异合成。

相似文献

1
Studies on the regulation of fatty acid and cholesterol synthesis in avian liver.鸟类肝脏中脂肪酸和胆固醇合成调控的研究。
Science. 1960 Aug 12;132(3424):418-9. doi: 10.1126/science.132.3424.418.
2
Studies on the relationship between glucose oxidation and intermediary metabolism. I. The influence of glycolysis on the synthesis of cholesterol and fatty acid in normal liver.葡萄糖氧化与中间代谢关系的研究。I.糖酵解对正常肝脏中胆固醇和脂肪酸合成的影响。
J Clin Invest. 1958 Aug;37(8):1185-95. doi: 10.1172/JCI103708.
3
Influence of diet on utilization of glucose and incorporation of acetate-I-C14 into liver fatty acids and cholesterol in rats.饮食对大鼠葡萄糖利用以及乙酸 -I -C14掺入肝脏脂肪酸和胆固醇的影响。
Am J Physiol. 1959 Jul;197(1):55-9. doi: 10.1152/ajplegacy.1959.197.1.55.
4
The incorporation of acetate-1-C14 into cholesterol and fatty acids by surviving tissues of normal and scorbutic guinea pigs.正常和坏血病豚鼠存活组织将乙酸盐 -1-C14 掺入胆固醇和脂肪酸的过程。
J Exp Med. 1956 Feb 1;103(2):199-205. doi: 10.1084/jem.103.2.199.
5
[Rate of conversion of acetate-1-C-14 CO2, cholesterol and fatty acid by rat liver slices rendered deficient in Co A].[缺乏辅酶A的大鼠肝切片对乙酸-1-C-14转化为二氧化碳、胆固醇和脂肪酸的速率]
Bull Soc Chim Biol (Paris). 1961;43:453-65.
6
Effect of adrenalectomy on the incorporation of acetate into fatty acids, cholesterol and acetoacetic acid by rat liver slices.肾上腺切除术对大鼠肝切片将乙酸盐掺入脂肪酸、胆固醇和乙酰乙酸的影响。
Am J Physiol. 1956 Jan;184(1):59-62. doi: 10.1152/ajplegacy.1955.184.1.59.
7
Effect of nicotinic acid and nicotinamide on incorporation of acetate into cholesterol, fatty acids and carbon dioxide by rat liver slices.烟酸和烟酰胺对大鼠肝切片中乙酸盐掺入胆固醇、脂肪酸和二氧化碳的影响。
Metabolism. 1960 Jul;9:686-9.
8
The effect of growth hormone administration and dietary protein on the incorporation of sodium acetate-2-C14 and mevalonic acid-2-C14 into liver cholesterol.生长激素给药和膳食蛋白质对乙酸钠-2-C14和甲羟戊酸-2-C14掺入肝脏胆固醇的影响。
Arch Biochem Biophys. 1961 Jan;92:81-6. doi: 10.1016/0003-9861(61)90221-1.
9
Alterations in cholesterol and fatty acid biosynthesis in rat liver homogenates by aryloxy acids.芳氧基酸对大鼠肝脏匀浆中胆固醇和脂肪酸生物合成的影响
Biochem J. 1974 Aug;142(2):445-8. doi: 10.1042/bj1420445.
10
[The metabolism of cholesterol and fatty acids in rat liver slices by the aid of labeled acetate].[借助标记醋酸盐研究大鼠肝切片中胆固醇和脂肪酸的代谢]
Pathol Biol. 1960 Mar;8:449-58.

引用本文的文献

1
Effect of a cholesterol-biosynthesis inhibitor on the fatty acid composition of phospholipids in the serum and tissue of rats.胆固醇生物合成抑制剂对大鼠血清和组织中磷脂脂肪酸组成的影响。
Biochem J. 1966 Mar;98(3):696-701. doi: 10.1042/bj0980696.