Gyrn J P, Olsen K S, Appelquist E, Chraemmer-Jørgensen B, Duus B, Berner Hansen L
Department of Anaesthesiology, Glostrup Hospital, University of Copenhagen, Denmark.
Acta Anaesthesiol Scand. 1992 Oct;36(7):643-6. doi: 10.1111/j.1399-6576.1992.tb03535.x.
The purpose of the study was to evaluate three different doses of intra-articular bupivacaine plus adrenaline in relation to per- and postoperative pain relief following arthroscopy. Sixty patients were allocated to three groups of 20 patients each scheduled for arthroscopy. They were randomized prospectively to receive bupivacaine plus adrenaline 25 mg + 50 micrograms, 50 mg + 100 micrograms, 75 mg + 150 micrograms, respectively, diluted to a volume of 30 ml. Four patients were excluded because the operation could not be carried out under intra-articular analgesia, 18 patients had a diagnostic arthroscopy and 38 patients had different arthroscopic operations performed. The number of patients scoring pain in the knee as moderate or severe was less in Group 3 than in the other two groups, i.e. the highest dose had a better pain relief. No adverse effects were registered. With respect to per- or postoperative administration of analgesics, postoperative pain occurrence, and the surgeon's acceptance of the method, there were no statistically significant differences. Ninety-two percent of the patients would prefer intraarticular analgesia if they should need to have another arthroscopy performed.
本研究的目的是评估关节腔内注射三种不同剂量布比卡因加肾上腺素在关节镜检查前后的止痛效果。60例患者被分为三组，每组20例，均计划接受关节镜检查。他们被前瞻性随机分配，分别接受25mg布比卡因加50μg肾上腺素、50mg布比卡因加100μg肾上腺素、75mg布比卡因加150μg肾上腺素，稀释至30ml。4例患者因无法在关节腔内镇痛下进行手术而被排除，18例患者接受了诊断性关节镜检查，38例患者进行了不同的关节镜手术。第3组中膝关节疼痛评分为中度或重度的患者数量少于其他两组，即最高剂量组的止痛效果更好。未记录到不良反应。在术前或术后使用镇痛药、术后疼痛发生率以及外科医生对该方法的接受程度方面，无统计学显著差异。92%的患者表示如果需要再次进行关节镜检查，他们更倾向于关节腔内镇痛。
