Bernsen H J, Verhagen W I, de Bijl M A, Heerschap A
Dept. of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
Acta Neurol Belg. 1992;92(4):207-14.
A 38-year-old layer of parquet flooring was referred because of memory impairment, tiredness and diffuse headaches. His work involved using several neurotoxic organic solvents. Extensive laboratory, neuropsychological, clinical neurophysiological, neuroadiological, magnetic resonance (MR) imaging and spectroscopy studies were performed. The neuropsychological and behavioural assessments showed an organic brain syndrome. MR imaging and CT scanning of the brain revealed enlarged ventricles and generalized atrophy. 31P and 1H MR spectroscopic measurements did not show any abnormalities. Owing to recent improvements regarding sensitivity and facilitated assignment, MR spectroscopy may provide in the near future significant additional information on brain metabolism in patients with brain dysfunction presumably induced by organic solvents.
一名38岁的镶木地板工人因记忆障碍、疲劳和弥漫性头痛前来就诊。他的工作涉及使用多种神经毒性有机溶剂。进行了广泛的实验室、神经心理学、临床神经生理学、神经放射学、磁共振（MR）成像和波谱研究。神经心理学和行为评估显示为器质性脑综合征。脑部的MR成像和CT扫描显示脑室扩大和广泛性萎缩。31P和1H MR波谱测量未显示任何异常。由于近期在灵敏度和赋值便利性方面的改进，MR波谱可能在不久的将来为推测由有机溶剂引起的脑功能障碍患者的脑代谢提供重要的额外信息。
