Rowlands D T, Berger J
J S Afr Vet Assoc. 1977 Jun;48(2):85-93.
A series of seven experiments designed to evaluate the anthelmintic efficacy of levamisole (1-tetramisole) by dermal application is described. This work involved use of 181 artificially infested calves. The drug was formulated at a concentration of 10% m/v levamisole base in a solvent system promoting dermal absorption and was applied to both sides of the spine in the lumber region at a dose rate of 10 mg levamisole base per kg livemass. A consistent performance was achieved in these investigations, the results from all of which were based upon necropsy findings. Efficacy of treatment was assessed against the third and fourth larval stages and fifth stage larvae/adult worms of six nematode species; the respective efficacies obtained were Haemonchus placei 72,0%; 99,3%; and 100%: Ostertagia ostertagi 85,5%; 38,1% and 74,5%: Cooperia spp. 98,9%; 99,9% and 100%: Bunostomum phlebotomum 83,0%; 100% and 98,5%: Oesophagostomum radiatum 47,4%; 94,9% and 99,6% and Dictyocaulus viviparus 79,5%; 94,1%; 90.9% (fifth stage larvae) and 93,8% (adult worms). The anthelmintic efficacy of levamisole in these experiments is of the same order as that achieved by orthodox methods of administration at dose rates between 7,5 and 10,0 mg levamisole HC1 per kg livemass. These findings add a new dimension to the use of levamisole and to anthelmintic therapy in general.
本文描述了一系列七项实验，旨在通过皮肤给药评估左旋咪唑（1-四咪唑）的驱虫效果。这项工作涉及使用181头人工感染的小牛。该药物在促进皮肤吸收的溶剂系统中配制成浓度为10%（m/v）的左旋咪唑碱，并以每千克活体重10毫克左旋咪唑碱的剂量率施用于腰部区域脊柱两侧。在这些研究中取得了一致的结果，所有结果均基于尸检结果。针对六种线虫的第三和第四幼虫阶段以及第五阶段幼虫/成虫评估了治疗效果；获得的相应疗效分别为：牛血矛线虫72.0%；99.3%；和100%：奥斯特他线虫85.5%；38.1%和74.5%：古柏属线虫98.9%；99.9%和100%：牛钩口线虫83.0%；100%和98.5%：辐射食道口线虫47.4%；94.9%和99.6%以及胎生网尾线虫79.5%；94.1%；90.9%（第五阶段幼虫）和93.8%（成虫）。在这些实验中，左旋咪唑的驱虫效果与通过每千克活体重7.5至10.0毫克盐酸左旋咪唑的传统给药方法所达到的效果相当。这些发现为左旋咪唑的使用以及一般驱虫治疗增添了新的维度。
