Berger J, Tema B O
J S Afr Vet Assoc. 1982 Sep;53(3):189-94.
In a series of 5 trials, in which 115 artificially infected calves were used, larval anthelmintic tests were done to assess the activity of oxfendazole at 4, 5 mg/kg against all 3 parasitic stages of 6 species of namatodes. An efficacy of over 98% was demonstrated against the 4th stage larvae (L4), 5th and adult stages of Haemonchus placei, Ostertagia ostertagi, Cooperia pectinata, Bunostomum Phlebotomum and Oesophagostomum radiatum and the 3rd larval stage (L3) of H. placei and C. pectinata. Against the L3 of O. ostertagi, B. phlebotomum and O. radiatum efficacies of 81,7%, 92,4% and 97,3% respectively were shown. Against Dictyocaulus viviparus adult, 5th, L4 and L3 efficacies were recorded of 100%, 96,7%, 95,4% and 89,1% respectively. A test for ovicidal activity confirmed that cattle can be safely moved to clean pasture 8 hours after dosing. Complete removal of strobilia of Moniezia benedeni from 25 naturally infested calves followed a dose rate of oxfendazole at 4,5 mg/kg, but of these each of 4 calves retained one scolex.
在一系列5项试验中，使用了115头人工感染的小牛，进行了幼虫驱虫试验，以评估4、5毫克/千克的奥芬达唑对6种线虫的所有3个寄生阶段的活性。结果表明，奥芬达唑对牛血矛线虫、奥氏奥斯特线虫、栉状古柏线虫、牛钩口线虫和辐射食道口线虫的第4期幼虫（L4）、第5期幼虫和成虫阶段，以及牛血矛线虫和栉状古柏线虫的第3期幼虫（L3）的驱虫效果超过98%。对奥氏奥斯特线虫、牛钩口线虫和辐射食道口线虫的L3的驱虫效果分别为81.7%、92.4%和97.3%。对胎生网尾线虫成虫、第5期幼虫、L4和L3的驱虫效果分别记录为100%、96.7%、95.4%和89.1%。杀卵活性试验证实，给药8小时后，牛可以安全转移到清洁牧场。以4.5毫克/千克的奥芬达唑剂量率给药后，25头自然感染的小牛的贝氏莫尼茨绦虫节片完全清除，但其中4头小牛各保留了一个头节。
