Kataoka Y, Hasegawa Y, Iwata H, Matsuda T, Genda E, Miura T, Takahashi H
Department of Orthopedics, Nagoya University School of Medicine, Japan.
Acta Orthop Scand. 1992 Oct;63(5):527-30. doi: 10.3109/17453679209154729.
We investigated the effects of hyperbaric oxygenation (HBO) on ischemic osteonecrosis and on ossification disturbance of the femoral heads in growing, spontaneously hypertensive rats (SHR). 10 male SHRs aged 5 weeks (Group A) and another 10 male SHRs aged 8 weeks (Group B) were treated with HBO at 2.8 atmosphere absolute (ATA) for 6 weeks in a total of 30 hours. The control animals, 10 male SHRs (Group C) and 10 male wistar Kyoto rats (WKY, Group D), were kept under normal laboratory conditions. All the rats were killed at the age of 17 weeks for microscopic examination. In Group A, there was no evidence of osteonecrosis, and only 2 femoral heads with ossification disturbance were observed. In Group B, there were 2 femoral heads with osteonecrosis and 1 with ossification disturbance. In contrast, there were 6 femoral heads with osteonecrosis and 4 with ossification disturbance in Group C. It was concluded that HBO prevented osteonecrosis and ossification disturbance of the femoral heads in SHR.
我们研究了高压氧疗（HBO）对生长中的自发性高血压大鼠（SHR）股骨头缺血性坏死和骨化紊乱的影响。10只5周龄雄性SHR（A组）和另外10只8周龄雄性SHR（B组）在2.8绝对大气压（ATA）下接受HBO治疗6周，共30小时。对照动物为10只雄性SHR（C组）和10只雄性京都Wistar大鼠（WKY，D组），饲养于正常实验室条件下。所有大鼠在17周龄时处死进行显微镜检查。A组未发现骨坏死证据，仅观察到2个股骨头有骨化紊乱。B组有2个股骨头发生骨坏死，1个有骨化紊乱。相比之下，C组有6个股骨头发生骨坏死，4个有骨化紊乱。得出的结论是，HBO可预防SHR股骨头的骨坏死和骨化紊乱。
