Iwasaki K, Hirano T
Department of Orthopaedic Surgery, Nagasaki University School of Medicine, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1988 Nov;62(11):1003-10.
The usefulness of spontaneously hypertensive rats (SHR) as a model animal for Perthes disease was evaluated because bone necrosis and ossification disturbance are frequently found in SHR. Twenty femoral heads from twenty-week-old male SHR were compared with twenty femoral heads from each control strain, Wistar Kyoto rat, Wistar rat and Donryu rat, in radiological and histological studies. SHR radiographs revealed flattening of the femoral head, radiolucent area and absence of trabeculae in the ossific nucleus as well as shortening and broadening of the neck. In the histological study of epiphysis in SHR, bone necrosis and various stages of its repair process and ossification disturbance represented the main findings. Incidence of these abnormal findings were significantly higher than in the control groups. Clarification of the causes of bone necrosis and ossification disturbance in SHR will provide a key to the understanding of the pathogenesis in Perthes disease.
由于自发性高血压大鼠（SHR）经常出现骨坏死和骨化障碍，因此对其作为佩吉特氏病模型动物的实用性进行了评估。在放射学和组织学研究中，将20只20周龄雄性SHR的股骨头与每种对照品系（Wistar Kyoto大鼠、Wistar大鼠和日本大耳白兔）的20个股骨头进行了比较。SHR的X光片显示股骨头扁平、出现透光区、骨化核内小梁缺失以及颈部缩短和变宽。在对SHR骨骺的组织学研究中，骨坏死及其修复过程的各个阶段以及骨化障碍是主要发现。这些异常发现的发生率明显高于对照组。阐明SHR骨坏死和骨化障碍的原因将为理解佩吉特氏病的发病机制提供关键线索。
