Suzumura E, Takeuchi K
Department of Otorhinolaryngology, Mie University School of Medicine, Tsu, Japan.
Acta Otolaryngol. 1992;112(3):552-8. doi: 10.3109/00016489209137439.
The change of ion transport in acute allergic reactions in vivo was studied by measuring the nasal transepithelial potential difference (PD) in patients with nasal allergy to Japanese cedar pollens. Comparison of nasal PD in the pollen season revealed a lower PD in the allergic patients than in the normal control subjects. We challenged the patients with allergen in the non-pollen season and measured the time course change of nasal PD and rate of inhibition of PD by amiloride and indomethacin. Nasal PD reached the lowest value 15 min after nasal allergen challenge. Percent inhibition of PD by amiloride was greater without the allergen challenge than it was in those patients after allergen challenge (51.7% versus 29.4%, p less than 0.01). Indomethacin did not change PD without allergen challenge, whereas it depressed nasal PD by 25.1% after allergen challenge. These results suggest that decreased sodium absorption and increased chloride secretion occur in local allergic reactions. Both changes may contribute to the increase in fluid transport towards the lumen, and this may lead to abnormalities of nasal secretion during acute allergic reactions.
通过测量对日本雪松花粉过敏的鼻过敏患者的鼻跨上皮电位差（PD），研究了体内急性过敏反应中离子转运的变化。花粉季节鼻PD的比较显示，过敏患者的PD低于正常对照受试者。我们在非花粉季节用过敏原刺激患者，并测量鼻PD的时间进程变化以及氨氯地平和吲哚美辛对PD的抑制率。鼻过敏原激发后15分钟，鼻PD达到最低值。无过敏原激发时氨氯地平对PD的抑制百分比高于过敏原激发后的患者（51.7%对29.4%，p<0.01）。无过敏原激发时吲哚美辛不改变PD，而过敏原激发后可使鼻PD降低25.1%。这些结果表明，局部过敏反应中钠吸收减少和氯分泌增加。这两种变化可能都有助于向管腔的液体转运增加，这可能导致急性过敏反应期间鼻分泌物异常。
