Rao M R, Jiang H, Shui B
Department of Cardiovascular Pharmacology, Nanjing Medical College.
Yao Xue Xue Bao. 1992;27(4):241-5.
The protective effects of m-Nif 15, 30 and 50 micrograms.kg-1 and of Nif 30 micrograms.kg-1 on experimental myocardial infarction and metabolism in rabbits were evaluated. Blood samples were collected simultaneously from the femoral artery and the coronary sinus for examining lactate and potassium balance. In the normal group (n = 8) and the sham ligated group (n = 5), the lactate balance were +17 +/- 1.0 and + 13 +/- 1.1% respectively and the potassium balance were +2.1 +/- 0.08 and +2.4 +/- 0.08%, respectively. After occlusion of the LAD, the lactate and K+ balance reduced to -196 +/- 60.2 and -83.0 +/- 8.2% respectively, and m-Nif produced a dose dependent improvement of both balance. After giving m-Nif 15, 30 and 50 micrograms.kg-1 i.v., the lactate balance improved to -60 +/- 9, -48 +/- 6.7 and -24 +/- 1.8% and the K+ balance went up to -32.2 +/- 2.1, -17.6 +/- 0.1, -3.3 +/- 0.06, respectively. In the mean time, Nif 30 micrograms.kg-1 i.v. improved the lactate and K+ balances to -52 +/- 8.6% and -36.4 +/- 3.1%. In another experiment, propranolol 1 mg.kg-1 i.v. improved the lactate balance to -18 +/- 1.2% while the K+ balance increased to +2.0 +/- 0.05%. The area of the myocardial infarct was measured by nitroblue tetrazolium (N-BT) technique 24 h after LAD occlusion.2+ angina pectoris.
评估了15、30和50微克·千克⁻¹的间硝苯地平（m-Nif）以及30微克·千克⁻¹的硝苯地平（Nif）对兔实验性心肌梗死和代谢的保护作用。同时从股动脉和冠状窦采集血样以检测乳酸和钾平衡。正常组（n = 8）和假结扎组（n = 5）的乳酸平衡分别为+17±1.0%和+13±1.1%，钾平衡分别为+2.1±0.08%和+2.4±0.08%。左前降支（LAD）闭塞后，乳酸和钾平衡分别降至-196±60.2%和-83.0±8.2%，且间硝苯地平使两者平衡呈剂量依赖性改善。静脉注射15、30和50微克·千克⁻¹的间硝苯地平后，乳酸平衡分别改善至-60±9%、-48±6.7%和-24±1.8%，钾平衡分别升至-32.2±2.1%、-17.6±0.1%、-3.3±0.06%。同时，静脉注射30微克·千克⁻¹的硝苯地平使乳酸和钾平衡分别改善至-52±8.6%和-36.4±3.1%。在另一实验中，静脉注射1毫克·千克⁻¹的普萘洛尔使乳酸平衡改善至-18±1.2%，而钾平衡增至+2.0±0.05%。在LAD闭塞24小时后，通过硝基蓝四氮唑（N-BT）技术测量心肌梗死面积。2+型心绞痛。
