Chen Q C, Chen W L, Dai Y Q, Ge G Q, Lin D C
Zhongshan Hospital, Shanghai Medical University.
Yao Xue Xue Bao. 1992;27(4):299-302.
A high-performance liquid chromatographic analysis of phenylpropanolamine (PPA) in human plasma is presented. Using direct UV detection the method is sufficiently sensitive to 25 ng/ml for PPA. Single-dose pharmacokinetics of PPA in 10 healthy volunteers taking controlled release suspension (C) or tablet (T), each containing 150 mg PPA was compared. The study described here has shown that the (C) AUC(0-infinity)/(T) AUC(0-infinity) = 1.02 (P greater than 0.4). The controlled-release product of PPA is equivalent to PPA tablet.
本文介绍了人血浆中苯丙醇胺（PPA）的高效液相色谱分析方法。采用直接紫外检测法，该方法对PPA的检测灵敏度足以达到25 ng/ml。比较了10名健康志愿者服用控释混悬液（C）或片剂（T）（均含150 mg PPA）后PPA的单剂量药代动力学。此处描述的研究表明，（C）的AUC(0-无穷大)/（T）的AUC(0-无穷大)=1.02（P>0.4）。PPA的控释产品与PPA片剂等效。
