Shen Y X, Xu C D, Gao X H, Lin D C, Liu G L
Department of Clinical Pharmacology, Changhai Hospital, Second Military Medical University, Shanghai.
Yao Xue Xue Bao. 1995;30(2):157-60.
Compared studies between the pharmacokinetics of phenylpropanolamine (PPA) controlled release suspension (CRS) and that of PPA conventional tablet in 10 healthy volunteers showed that the maximal plasma concentration (Cmax), the minimal plasma concentration (Cmin) and the fluctuation index (FI) values were 169.06 +/- 7.76 ng.ml-1, 82.80 +/- 4.29 ng/ml-1 and 0.20 +/- 0.04 respectively for PPA CRS, 180.5 +/- 8.91 ng.ml-1, 76.18 +/- 5.97 ng.ml-1 and 0.81 +/- 0.07 respectively for the conventional tablet. The Cmax and FI of PPA CRS were significantly lower compared with those of the conventional tablet (P < 0.01) during steady state. The Cmin of PPA CRS was higher than that of the conventional tablet (P < 0.05).
在10名健康志愿者中对苯丙醇胺控释混悬液（CRS）和苯丙醇胺普通片剂的药代动力学进行比较研究，结果显示，苯丙醇胺控释混悬液的最大血药浓度（Cmax）、最小血药浓度（Cmin）和波动指数（FI）值分别为169.06±7.76 ng.ml-1、82.80±4.29 ng/ml-1和0.20±0.04，普通片剂分别为180.5±8.91 ng.ml-1、76.18±5.97 ng.ml-1和0.81±0.07。在稳态时，苯丙醇胺控释混悬液的Cmax和FI显著低于普通片剂（P<0.01）。苯丙醇胺控释混悬液的Cmin高于普通片剂（P<0.05）。
