Chuang L M, Wu H P, Chiou G C
Department of Internal Medicine, National Taiwan University Hospital, Taipei, China.
Zhongguo Yao Li Xue Bao. 1992 May;13(3):193-7.
Hypoglycemic crisis is a common occurrence in diabetic patients. In order to reverse the hypoglycemia, glucagon eyedrops at concentrations of 2.5%, 5.0%, and 7.5% were instilled to the eyes of diabetic patients who were fasted overnight. The glucagon eyedrops raised the blood glucose efficiently in a dose-dependent manner and peaked at 30 min after drug instillation. At 2.5%, glucagon raised the blood glucose 0.83 mmol.L-1 which exceeded the minimal requirement of 0.56 mmol.L-1 increase in blood glucose level at hypoglycemic crisis. At 5.0% and 7.5%, glucagon eyedrops increased the blood glucose level further to 1.76 and 1.91 mmol.L-1, respectively. These results indicate that glucagon can be delivered effectively through ocular route to raise the systemic blood glucose for the treatment of hypoglycemic crisis.
低血糖危象在糖尿病患者中很常见。为了逆转低血糖，将浓度为2.5%、5.0%和7.5%的胰高血糖素滴眼液滴入隔夜禁食的糖尿病患者眼中。胰高血糖素滴眼液以剂量依赖的方式有效提高血糖水平，并在滴药后30分钟达到峰值。在2.5%的浓度下，胰高血糖素使血糖升高0.83 mmol.L-1，超过了低血糖危象时血糖水平升高0.56 mmol.L-1的最低要求。在5.0%和7.5%的浓度下，胰高血糖素滴眼液分别使血糖水平进一步升高至1.76和1.91 mmol.L-1。这些结果表明，胰高血糖素可以通过眼部途径有效递送，以提高全身血糖水平来治疗低血糖危象。
