Stratos C, Stefanadis C, Kallikazaros I, Boudoulas H, Toutouzas P
Department of Cardiology, University of Athens Medical School, Hippokration Hospital, Greece.
Am J Med. 1992 Nov;93(5):505-12. doi: 10.1016/0002-9343(92)90577-x.
The purpose of the present investigation was to study the distensibility of the ascending aorta in patients with arterial hypertension and normal subjects before and after administration of a calcium antagonist, nifedipine.
The distensibility of the ascending aorta was measured before and after nifedipine administration in 22 male hypertensive patients and 12 age-matched male normotensive subjects. Aortic distensibility was calculated as a function of changes in aortic diameter and pulse pressure, using the formula: 2 x (pulsatile change in aortic diameter)/[(diastolic aortic diameter) x (aortic pulse pressure)]. Aortic diameters were measured by echocardiography and aortic pressures were obtained by catheterization of the ascending aorta.
In the basal state, the distensibility of the ascending aorta and aortic strain were lower in hypertensive patients than in normotensive subjects (p < 0.001); the lower aortic distensibility, however, was associated with a greater distending pressure. A good inverse correlation (r = -0.81) was found between mean aortic pressure and aortic distensibility. The aortic distensibility was increased after nifedipine administration in both groups; this increase in aortic distensibility, however, was lower in the patients with hypertension compared with normotensive subjects (p < 0.001).
Aortic distensibility is decreased in patients with arterial hypertension. Nifedipine administration increased the distensibility of the ascending aorta both in patients with arterial hypertension and in normotensive subjects. The increase of aortic distensibility after nifedipine administration was lower in hypertensive patients.
本研究旨在探讨钙拮抗剂硝苯地平给药前后，动脉高血压患者和正常受试者升主动脉的扩张性。
对22例男性高血压患者和12例年龄匹配的男性正常血压受试者在硝苯地平给药前后测量升主动脉的扩张性。主动脉扩张性根据主动脉直径和脉压的变化来计算，使用公式：2×（主动脉直径的搏动变化）/[（舒张期主动脉直径）×（主动脉脉压）]。主动脉直径通过超声心动图测量，主动脉压力通过升主动脉插管获得。
在基础状态下，高血压患者升主动脉的扩张性和主动脉应变低于正常血压受试者（p<0.001）；然而，较低的主动脉扩张性与较高的扩张压力相关。平均主动脉压力与主动脉扩张性之间存在良好的负相关（r=-0.81）。两组在硝苯地平给药后主动脉扩张性均增加；然而，高血压患者主动脉扩张性的增加低于正常血压受试者（p<0.001）。
动脉高血压患者的主动脉扩张性降低。硝苯地平给药可增加动脉高血压患者和正常血压受试者升主动脉的扩张性。高血压患者硝苯地平给药后主动脉扩张性的增加较低。
