Cardiac and Medical Departments, Sapienza Sapienza University, Rome, Italy.
Heart. 2010 Sep;96(18):1469-74. doi: 10.1136/hrt.2010.198358. Epub 2010 Jul 18.
Aortic stiffness may be associated with an increased incidence of cardiovascular events and has been reported to be related to arterial wall motion velocities as measured by tissue Doppler imaging.
To investigate the potential clinical application of tissue Doppler imaging (TDI) for assessment of aortic function parameters in healthy and hypertensive adults.
110 hypertensive and 80 healthy adults were examined. Pulse wave velocity (PWV) and augmentation index (Aix) were measured as standard parameters of arterial stiffness by an oscillometric system. Aortic M-mode and TDI parameters were measured. Aortic distensibility (D) and aortic stiffness index (SI) were calculated using accepted formulae. Anterior wall aortic expansion velocity (S(Ao)), acceleration time (AT(Ao)), early (E(Ao)) and late (A(Ao)) diastolic retraction velocity and peak systolic radial strain (epsilon(Ao)) were determined. Comprehensive echocardiography was performed for the assessment of left ventricular (LV) systolic/diastolic function.
S(Ao), E(Ao) and e(Ao) were significantly lower in hypertensive subjects (p<.001, p<.001, and p<.0001, respectively). Reduced D (p<.05 vs controls) and increased PWV (p<.05 vs controls) and SI (p<.01 vs controls) were consistent with evidence of increased aortic stiffness in both male and female hypertensive patients. PWV and Aix increased and D decreased with increasing age or systolic blood pressure. Multivariate analysis showed epsilon(Ao) to be independently related (R2 = 0.63) to pulse pressure, LV mass index and diastolic function.
Ascending aorta TDI provides wall velocity and strain data differentiating hypertensive from healthy adults and reflecting aortic compliance changes related to age and sex and LV diastolic function.
主动脉僵硬度可能与心血管事件的发生率增加有关，并已报道与组织多普勒成像（TDI）测量的动脉壁运动速度有关。
研究组织多普勒成像（TDI）在评估健康和高血压成年人主动脉功能参数中的潜在临床应用。
检查了 110 名高血压患者和 80 名健康成年人。通过示波系统测量脉搏波速度（PWV）和增强指数（Aix）作为动脉僵硬度的标准参数。测量主动脉 M 型和 TDI 参数。使用公认的公式计算主动脉可扩张性（D）和主动脉僵硬度指数（SI）。确定主动脉前壁扩张速度（S（Ao））、加速度时间（AT（Ao））、早期（E（Ao））和晚期（A（Ao））舒张回缩速度和收缩期径向应变峰值（epsilon（Ao））。进行综合超声心动图评估左心室（LV）收缩/舒张功能。
高血压患者的 S（Ao）、E（Ao）和 e（Ao）明显降低（p<.001，p<.001 和 p<.0001，分别）。降低的 D（p<.05 与对照组）和增加的 PWV（p<.05 与对照组）和 SI（p<.01 与对照组）与男性和女性高血压患者主动脉僵硬度增加的证据一致。PWV 和 Aix 随着年龄或收缩压的增加而增加，D 随着年龄或收缩压的增加而降低。多元分析显示 epsilon（Ao）与脉压、LV 质量指数和舒张功能独立相关（R2 = 0.63）。
升主动脉 TDI 提供区分高血压和健康成年人的壁速度和应变数据，并反映与年龄和性别以及 LV 舒张功能相关的主动脉顺应性变化。
