Gram I T, Macaluso M, Stalsberg H
Institute of Community Medicine, University of Tromsö, Norway.
Am J Obstet Gynecol. 1992 Jul;167(1):40-4. doi: 10.1016/s0002-9378(11)91622-6.
Our objective was to examine the relationship between oral contraceptive use and the incidence of cervical intraepithelial neoplasia.
In a prospective follow-up study of 6622 women participating in the Second Tromsö Study conducted in 1979 and 1980 in Tromsö, Norway, women aged 20 to 49 years answered a questionnaire regarding their smoking history, dietary habits, alcohol consumption, and oral contraceptive use. They were then followed for 10 years with data from the Pathology Registry of the University Hospital.
The age-adjusted incidence rate of cervical intraepithelial neoplasia was 897 per 100,000 person years among noncurrent and 1295 per 100,000 person years among current oral contraceptive users as of 1979. After adjusting for age, marital status, smoking, and frequency of alcohol intoxication the relative rate for current users was 1.5 (95% confidence interval 1.1 to 2.1), and the relative rate for past users was 1.4 (95% confidence interval 1.0 to 1.8), as compared with those who had never used oral contraceptives before 1979.
These findings support the hypothesis that the occurrence of cervical intraepithelial neoplasia is increased by oral contraceptive use.
我们的目的是研究口服避孕药的使用与宫颈上皮内瘤变发病率之间的关系。
在1979年和1980年于挪威特罗姆瑟进行的第二项特罗姆瑟研究中，对6622名年龄在20至49岁之间的女性进行了前瞻性随访研究。这些女性回答了一份关于她们吸烟史、饮食习惯、饮酒情况和口服避孕药使用情况的问卷。然后利用大学医院病理登记处的数据对她们进行了10年的随访。
截至1979年，非当前口服避孕药使用者中宫颈上皮内瘤变的年龄调整发病率为每10万人年897例，当前口服避孕药使用者中为每10万人年1295例。在对年龄、婚姻状况、吸烟和酒精中毒频率进行调整后，与1979年以前从未使用过口服避孕药的女性相比，当前使用者的相对发病率为1.5（95%置信区间为1.1至2.1），过去使用者的相对发病率为1.4（95%置信区间为1.0至1.8）。
这些发现支持了口服避孕药使用会增加宫颈上皮内瘤变发生率这一假设。
