Cowchock F S, Smith J B
Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania.
Am J Obstet Gynecol. 1992 Nov;167(5):1208-12. doi: 10.1016/s0002-9378(11)91690-1.
Our objective was to determine whether results from tests for maternal serum antinuclear antibodies, cytotoxic antibodies to paternal lymphocytes, parental histocompatibility types, and blocking factors for maternal-paternal mixed lymphocyte reactions were predictive of pregnancy outcome without immunologic treatment. Pregnancy outcome data from 95 women with a history of unexplained recurrent spontaneous abortions who underwent immunologic tests at Jefferson Medical College were evaluated with multiple logistic regression analyses. The number of prior spontaneous abortions, history of another relevant diagnosis, parental sharing of one histocompatibility antigen, and maternal age were related to the outcome of the next pregnancy in women given no immunologic treatment (p = 0.05). No significant correlation was found between results from the immunologic tests or other history characteristics evaluated and outcome of the next pregnancy. The immunologic tests evaluated were not clinically useful predictors of pregnancy outcome.
我们的目的是确定在未进行免疫治疗的情况下，母体血清抗核抗体检测、针对父方淋巴细胞的细胞毒性抗体检测、亲代组织相容性类型检测以及母体 - 父方混合淋巴细胞反应阻断因子检测的结果是否能预测妊娠结局。对95名有不明原因复发性自然流产史且在杰斐逊医学院接受免疫检测的女性的妊娠结局数据进行了多因素逻辑回归分析。在未接受免疫治疗的女性中，既往自然流产次数、其他相关诊断史、亲代共享一种组织相容性抗原以及母体年龄与下一胎妊娠结局相关（p = 0.05）。在所评估的免疫检测结果或其他病史特征与下一胎妊娠结局之间未发现显著相关性。所评估的免疫检测在临床上并非妊娠结局的有效预测指标。
