Eroglu G, Betz G, Torregano C
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112-2822.
Am J Obstet Gynecol. 1992 May;166(5):1364-9. doi: 10.1016/0002-9378(92)91605-a.
The role of histocompatibility antigens in pregnancy outcome is controversial. This controversy may be because the initial studies were of small numbers or the patient groups were not homogeneous. The purpose of this study is to clarify these discrepant results by carrying out histocompatibility antigen typing and mixed lymphocyte culture on couples with idiopathic recurrent spontaneous abortion and by comparing results with those of fertile couples.
Sixty couples with at least three spontaneous abortions and 60 normal couples with at least two successful pregnancies were included. Histocompatibility antigen typing and mixed lymphocyte culture were performed by using the standard techniques. The data were analyzed statistically with the Fisher exact test and chi 2.
Our results failed to show any difference between normal and aborting couples with regard to HLA-A, HLA-B, and HLA-DR distribution or sharing or to mixed lymphocyte culture responsiveness.
Our study, along with other studies, emphasizes that the histocompatibility antigen system does not have an impact on pregnancy outcome.
组织相容性抗原在妊娠结局中的作用存在争议。这种争议可能是因为最初的研究样本量小，或者患者群体不具有同质性。本研究的目的是通过对特发性复发性自然流产夫妇进行组织相容性抗原分型和混合淋巴细胞培养，并将结果与可育夫妇的结果进行比较，来澄清这些相互矛盾的结果。
纳入60对至少有三次自然流产的夫妇和60对至少有两次成功妊娠的正常夫妇。采用标准技术进行组织相容性抗原分型和混合淋巴细胞培养。数据采用Fisher精确检验和卡方检验进行统计学分析。
我们的结果未能显示正常夫妇与流产夫妇在HLA - A、HLA - B和HLA - DR分布、共享或混合淋巴细胞培养反应性方面存在任何差异。
我们的研究以及其他研究强调，组织相容性抗原系统对妊娠结局没有影响。
