Cline B L, Hernandez J L, Mather F J, Bartholomew R, De Maza S N, Rodulfo S, Welborn C A, Eberhard M L, Convit J
Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University Medical Center, New Orleans, Louisiana.
Am J Trop Med Hyg. 1992 Oct;47(4):512-20. doi: 10.4269/ajtmh.1992.47.512.
A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection. Forty-nine patients (26 treated and 23 controls) received a 10-day course of albendazole (400 mg/day) or a placebo. Consistent with the excellent tolerance observed, albendazole did not kill microfilariae. However, analysis of changes in microfilarial densities (mf/mg of skin) over one year showed that albendazole was active against O. volvulus, presumably by interfering with embryogenesis. The nature, degree, and duration of this effect remain to be determined.
在委内瑞拉的莫纳加斯州进行了一项双盲临床试验，以评估阿苯达唑治疗盘尾丝虫感染的耐受性和疗效。49名患者（26名接受治疗，23名作为对照）接受了为期10天的阿苯达唑疗程（400毫克/天）或安慰剂治疗。与观察到的良好耐受性一致，阿苯达唑并未杀死微丝蚴。然而，对一年内微丝蚴密度（每毫克皮肤中的微丝蚴数）变化的分析表明，阿苯达唑对盘尾丝虫有活性，可能是通过干扰胚胎发生起作用。这种作用的性质、程度和持续时间仍有待确定。
