Awadzi K, Hero M, Opoku O, Büttner D W, Gilles H M
Onchocerciasis Chemotherapeutic Research Centre, Hohoe Hospital, Ghana.
Trop Med Parasitol. 1991 Dec;42(4):356-60.
Ninety-two males, infected with Onchocerca volvulus, from an area of on-going transmission in the forest zone of southern Ghana were treated with albendazole. 31 patients received 800 mg daily x 3, 31 received 1200 mg daily x 3 and 30 others received 800 mg daily x 7. Albendazole was given as a single daily dose with a fatty breakfast. Detailed systemic, ocular and laboratory examinations were performed pretreatment and at intervals over one year. Nodules were extirpated on days 30 and 60 and examined by histopathology. All the dose regimes were well tolerated but were neither microfilaricidal nor macrofilaricidal. The main effect was embryotoxicity affecting all intra-uterine stages. The most encouraging results were obtained in the 800 mg daily x 3 group in which a prolonged suppression of skin microfilarial counts occurred. Controlled studies in combination with ivermectin are recommended to determine whether an additive effect of the two drugs would result in permanent sterilisation of the adult worms.
来自加纳南部森林地区一个盘尾丝虫病正在传播区域的92名感染盘尾丝虫的男性患者接受了阿苯达唑治疗。31名患者每日服用800毫克，共3天；31名患者每日服用1200毫克，共3天；另外30名患者每日服用800毫克，共7天。阿苯达唑作为每日单次剂量，与一份富含脂肪的早餐一起服用。在治疗前以及治疗后的一年时间里定期进行详细的全身、眼部和实验室检查。在第30天和第60天摘除结节并进行组织病理学检查。所有剂量方案耐受性良好，但既不杀微丝蚴也不杀成虫。主要作用是胚胎毒性，影响所有子宫内阶段。在每日800毫克、共3天的治疗组中获得了最令人鼓舞的结果，该组皮肤微丝蚴计数出现了长期抑制。建议开展与伊维菌素联合使用的对照研究，以确定这两种药物的相加作用是否会导致成虫永久性绝育。
