Melina D, Guerrera G, Santoliquido A, Guerrera C, Musumeci V, Nicolò G, Cataldo R
Institut de Pathologie Médicale, Université Catholique du Sacré-Coeur, Rome.
Ann Cardiol Angeiol (Paris). 1992 Jun;41(6):351-3.
The antihypertensive efficacy of combination therapy with N-E-A was evaluated during 6 months in 15 patients with hypertension associated with mild to moderate kidney failure. After 6 months a significant reduction of SBP and DBP (p < 0.001), with improvement of creatinine clearance and with no adverse effects on ECG, heart rate and routine laboratory tests test, was observed in 3 patients treated with N 20 mg x 2/d + E 10 mg/d + A 50 mg/d and in 8 patients treated with N 20 mg x 3 + E 10 mg x 2, + A 50 mg x 2. Four patients did not respond to this therapy.
在15例伴有轻至中度肾衰竭的高血压患者中，对N-E-A联合治疗的降压疗效进行了为期6个月的评估。6个月后，在接受N 20mg×2/日+E 10mg/日+A 50mg/日治疗的3例患者以及接受N 20mg×3+E 10mg×2+A 50mg×2治疗的8例患者中，观察到收缩压和舒张压显著降低（p<0.001），肌酐清除率改善，且对心电图、心率和常规实验室检查无不良影响。4例患者对该治疗无反应。
