Guerin C, Genin C, Sabatier J C, Toulon J, Leroy G, Berthoux F
Nephrologie. 1987;8(1):19-22.
We report our experience with a converting-enzyme inhibitor, enalapril, as antihypertensive agent in eighteen patients with hypertension after renal transplantation. Renal function was prospectively followed up. Six patients demonstrated an acute renal failure episode (defined by a 25% increase of serum creatinine during enalapril therapy). Renal failure was always reversible with interruption or dosage reduction of the drug. We recommend to start therapy with low dose and to closely monitor renal function.
我们报告了在18例肾移植术后高血压患者中使用转换酶抑制剂依那普利作为抗高血压药物的经验。对肾功能进行了前瞻性随访。6例患者出现急性肾衰竭发作（定义为依那普利治疗期间血清肌酐升高25%）。肾衰竭总是通过中断或减少药物剂量而可逆。我们建议以低剂量开始治疗并密切监测肾功能。
