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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Orita K, Sakagami K, Fuchimoto S, Arima T, Tanaka S

Acta Med Okayama. 1977 Jun;31(3):177-86.

Three cases of acute rejection were detected by macrophage migration inhibition tests (MIT) conducted directly on seven patients who had received renal allografts. The macrophage migration inhibitory factor (MIF) activity was positive in all cases 1-2 days before the appearance of acute rejection. 2. After the administration of a high dose of Solu-Medrol (1g/day for 3 days) to suppress the acute rejection, MIF activity recovered to its normal level 3 days later. These findings seem to indicate that MIT yields immunologically useful criteria for the early detection of an acute rejection.

对7例接受同种异体肾移植的患者直接进行巨噬细胞游走抑制试验（MIT），检测到3例急性排斥反应。在急性排斥反应出现前1 - 2天，所有病例的巨噬细胞游走抑制因子（MIF）活性均为阳性。2. 给予大剂量甲泼尼龙（1g/天，共3天）以抑制急性排斥反应后，MIF活性在3天后恢复到正常水平。这些发现似乎表明，MIT可为急性排斥反应的早期检测提供免疫学上有用的标准。

Orita K, Sakagami K, Fuchimoto S, Arima T, Tanaka S

Acta Med Okayama. 1977 Jun;31(3):177-86.

Three cases of acute rejection were detected by macrophage migration inhibition tests (MIT) conducted directly on seven patients who had received renal allografts. The macrophage migration inhibitory factor (MIF) activity was positive in all cases 1-2 days before the appearance of acute rejection. 2. After the administration of a high dose of Solu-Medrol (1g/day for 3 days) to suppress the acute rejection, MIF activity recovered to its normal level 3 days later. These findings seem to indicate that MIT yields immunologically useful criteria for the early detection of an acute rejection.

对7例接受同种异体肾移植的患者直接进行巨噬细胞游走抑制试验（MIT），检测到3例急性排斥反应。在急性排斥反应出现前1 - 2天，所有病例的巨噬细胞游走抑制因子（MIF）活性均为阳性。2. 给予大剂量甲泼尼龙（1g/天，共3天）以抑制急性排斥反应后，MIF活性在3天后恢复到正常水平。这些发现似乎表明，MIT可为急性排斥反应的早期检测提供免疫学上有用的标准。