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[胆囊收缩素、神经降压素和促肾上腺皮质激素释放因子,三种重要的厌食肽]

[Cholecystokinin, neurotensin and corticotropin-releasing factor, three important anorexic peptides].

作者信息

Beck B

机构信息

INSERM U.308, Mécanismes de Régulation du Comportement Alimentaire, Nancy.

出版信息

Ann Endocrinol (Paris). 1992;53(1):44-56.

PMID:1444178
Abstract

This paper updates the informations on the three most important anorexigenic peptides: cholecystokinin, neurotensin and corticotropin-releasing factor. Their peripheral and/or central effects on food and water intakes as well as on dietary preferences are detailed. Their mechanisms of action and regulation are examined. This includes the interactions with classical neurotransmitters (norepinephrine, dopamine, etc...) as well as the description of the brain nuclei and neuronal networks involved. Finally, their variations in disturbed feeding behavior (hyperphagia, anorexia) in man or in animal models are reviewed.

摘要

本文更新了三种最重要的厌食肽的信息

胆囊收缩素、神经降压素和促肾上腺皮质激素释放因子。详细阐述了它们对食物和水摄入量以及饮食偏好的外周和/或中枢作用。研究了它们的作用机制和调节方式。这包括与经典神经递质(去甲肾上腺素、多巴胺等)的相互作用以及对所涉及的脑核和神经网络的描述。最后,综述了它们在人类或动物模型中摄食行为紊乱(食欲亢进、厌食)时的变化情况。

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