Sullivan A C, Gruen R K
Fed Proc. 1985 Jan;44(1 Pt 1):139-44.
The regulation of appetite is a complex process that we are just beginning to understand. It consists of both central and peripheral elements and involves the integration by the brain of a variety of signals from peripheral organs transmitted by neurotransmitters, peptides, hormones, and metabolites. All available anorectic drugs act by central mechanisms and have several disadvantages including limited effectiveness, side effects on the central nervous system, the development of tolerance, abuse potential, and rebound hyperphagia on discontinuance. Several appetite-modulating agents have been tested in animals that act by peripheral mechanisms and do not produce tolerance or rebound hyperphagia, which suggests that peripherally acting anorectic drugs may provide novel therapeutic approaches to disorders of appetite regulation in humans.
食欲调节是一个复杂的过程，我们才刚刚开始了解。它包括中枢和外周因素，涉及大脑对由神经递质、肽、激素和代谢物传递的来自外周器官的各种信号的整合。所有现有的食欲抑制药物都通过中枢机制起作用，并且有几个缺点，包括效果有限、对中枢神经系统的副作用、耐受性的发展、滥用潜力以及停药后的反弹性食欲亢进。几种通过外周机制起作用且不会产生耐受性或反弹性食欲亢进的食欲调节药物已在动物身上进行了测试，这表明作用于外周的食欲抑制药物可能为人类食欲调节障碍提供新的治疗方法。
