Takata S
Acta Med Okayama. 1977 Jun;31(3):187-202.
Twenty cases of suspected drug induced liver injury (16 cases of which satisfied the criteria for at least a query positive diagnosis as based on the Fourth Congress of "Drugs and the Liver" in Japan) were studied by the whole blood culture technique of lumphocyte blast transformation. The positive rate with this technique was 10%, and no more than 15% even with the addition of one query positive. One reason for the low positive rate was that there was not only an allergic mechanism at work in the study group but that liver injury due to direct cytotoxicity of the drug was involved also. For a drug such as chlorpromazine with strong cytotoxicity for lymphocytes, it was difficult to demonstrate a relationship between allergic mechanisms and the drug with this method.
对20例疑似药物性肝损伤病例（其中16例符合日本“药物与肝脏”第四届大会制定的至少疑似阳性诊断标准）采用淋巴细胞转化全血培养技术进行研究。该技术的阳性率为10%，即使增加一例疑似阳性病例，阳性率也不超过15%。阳性率低的一个原因是，研究组中不仅存在过敏机制，还涉及药物直接细胞毒性导致的肝损伤。对于像氯丙嗪这样对淋巴细胞有强细胞毒性的药物，用这种方法很难证明过敏机制与该药物之间的关系。
