仙鹤草素，一种龙芽草属植物的抗肿瘤单宁，可诱导白细胞介素-1。
Agrimoniin, an antitumor tannin of Agrimonia pilosa Ledeb., induces interleukin-1.
作者信息
Murayama T, Kishi N, Koshiura R, Takagi K, Furukawa T, Miyamoto K
机构信息
Department of Microbiology, Kanazawa Medical University, Ishikawa, Japan.
出版信息
Anticancer Res. 1992 Sep-Oct;12(5):1471-4.
The induction of interleukin-1 (IL-1) by agrimoniin, a tannin of Agrimonia pilosa Ledeb., in human peripheral blood mononuclear cells (PBMC) in vitro and in mouse adherent peritoneal exudate cells (PEC) in vivo was studied. A significant amount of IL-1 beta in the culture supernatant of the human PBMC stimulated with agrimoniin was detected with an enzyme-linked immunoadherent assay. Agrimoniin induced IL-1 beta secretion dose- and time-dependently. The adherent PEC from mice intraperitoneally injected with agrimoniin (10 mg/kg) also secreted IL-1 4 days later. These results suggest that agrimoniin, a plant tannin, is a novel cytokine inducer.
研究了龙牙草中的一种单宁——仙鹤草素在体外对人外周血单核细胞（PBMC）以及在体内对小鼠黏附性腹腔渗出细胞（PEC）诱导白细胞介素-1（IL-1）的情况。用酶联免疫吸附测定法检测到，用仙鹤草素刺激的人PBMC培养上清液中有大量IL-1β。仙鹤草素诱导IL-1β分泌呈剂量和时间依赖性。腹腔注射仙鹤草素（10 mg/kg）的小鼠的黏附性PEC在4天后也分泌IL-1。这些结果表明，植物单宁仙鹤草素是一种新型细胞因子诱导剂。
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