Cutilletta A F, Rudnik M, Arcilla R A, Straube R
Am J Physiol. 1977 Nov;233(5):H600-4. doi: 10.1152/ajpheart.1977.233.5.H600.
The effect of prophylactic digitalization on the development of left ventricular hypertrophy was studied in adult rats. Digitoxin, 0.1 mg/100 g body wt or solvent was given daily for 1 wk prior to either aortic constriction or sham operation and was continued until the animals were killed, either 1 or 4 wk after surgery. A hemodynamic study was done in those animals killed 1 wk after surgery; hearts of all animals were examined for evidence of myocardial hypertrophy. Constriction of the ascending aorta had no significant effect on cardiac output but did reduce peak flow velocity and flow acceleration. An increase in left ventricular mass, RNA, and hydroxyproline was found in the animals with aortic constriction. Digitoxin treatment did not alter peak flow velocity or flow acceleration, but did significantly increase isovolumic (dP/dt)P-1. Digitoxin had no effect on body weight, heart weight, RNA, or hydroxyproline in either the sham-operated animals or in the animals with aortic constriction. Therefore, despite plasma digitoxin levels sufficient to affect myocardial contractility, left ventricular hypertrophy still developed after aortic constriction.
在成年大鼠中研究了预防性洋地黄化对左心室肥厚发展的影响。在主动脉缩窄或假手术前1周，每天给予地高辛，剂量为0.1mg/100g体重或溶剂，持续至动物被处死，即在手术后1周或4周。对手术后1周处死的动物进行血流动力学研究；检查所有动物的心脏有无心肌肥厚的证据。升主动脉缩窄对心输出量无显著影响，但确实降低了峰值流速和血流加速度。在主动脉缩窄的动物中发现左心室质量、RNA和羟脯氨酸增加。地高辛治疗未改变峰值流速或血流加速度，但确实显著增加了等容（dP/dt）P-1。地高辛对假手术动物或主动脉缩窄动物的体重、心脏重量、RNA或羟脯氨酸均无影响。因此，尽管血浆地高辛水平足以影响心肌收缩力，但主动脉缩窄后仍出现左心室肥厚。
