Matsumoto H, Yonemura Y, Kosaka T, Muraoka K, Kaji M, Nakai M, Tsugawa K, Segawa M, Fushida S, Takano Y
Second Department of Surgery, School of Medicine, Kanazawa University, Japan.
Gan To Kagaku Ryoho. 1992 Nov;19(13):2227-30.
CDDP, MMC, UFT and Etoposide (PMUE)-combined therapy was given to a 62-year-old man with advanced gastric carcinoma. PMUE therapy consists of i.v. injection of CDDP 75 mg/m2 and MMC 10 mg/body on day 1, i.v. injection of Etoposide 50 mg/body on days 3, 4 and 5 and consecutive daily administration of UFT 400 mg/body, with 3 weeks as one course. He was admitted for Borrmann type 3 gastric carcinoma with multiple liver metastasis, lymph node metastases and peritoneal dissemination, the underwent total gastrectomy with R2 lymph node dissection. He was treated four times with this therapy after sensitivity test for carcinostatic agents (SDI test), which resulted in complete remission, as confirmed by CT scan and second-look operation. The patient has currently been free of disease, and we conclude that this PMUE therapy is extremely effective for advanced gastric carcinoma.
对一名62岁的晚期胃癌男性患者采用顺铂、丝裂霉素、优福定和依托泊苷（PMUE）联合疗法。PMUE疗法包括在第1天静脉注射顺铂75mg/m²和丝裂霉素10mg/体，在第3、4和5天静脉注射依托泊苷50mg/体，连续每日给予优福定400mg/体，以3周为一个疗程。他因Borrmann 3型胃癌伴多发肝转移、淋巴结转移和腹膜播散入院，接受了R2淋巴结清扫的全胃切除术。在进行抗癌药敏感性试验（SDI试验）后，他接受了4次这种疗法，CT扫描和二次探查手术证实完全缓解。该患者目前无疾病，我们得出结论，这种PMUE疗法对晚期胃癌极其有效。
