Chaubert P, Hurlimann J
Department of Pathology, University of Lausanne, Switzerland.
Arch Pathol Lab Med. 1992 Nov;116(11):1181-8.
Zinc-alpha 2-glycoprotein, gross cystic disease fluid protein 15, and estrogen receptors are expressed in a great proportion of breast carcinomas. These markers were investigated by immunohistochemistry in 28 metastases from breast carcinomas and for comparison on 24 metastases from other carcinomas. A group of 83 primary nonmammary tumors was also studied. Most (> 96%) breast carcinoma metastases expressed one or several markers, while all metastases of other origins were negative. This sensitive and apparently specific immunostaining proved to be of great utility in cases in which the mammary origin of metastases was difficult to establish. In four axillary lymph node metastases, it even led to the discovery of an occult homolateral breast carcinoma that was not detectable by clinical and mammographic investigations. This study indicates that the combined use of zinc-alpha 2-glycoprotein, gross cystic disease fluid protein 15, and estrogenic receptors represents a useful immunostaining technique that can help the pathologist in determining the origin of breast carcinoma metastases.
锌-α2-糖蛋白、巨大囊肿病液体蛋白15和雌激素受体在很大比例的乳腺癌中表达。通过免疫组织化学对28例乳腺癌转移灶进行了这些标志物的研究，并与24例其他癌转移灶作比较。还研究了一组83例原发性非乳腺肿瘤。大多数（>96%）乳腺癌转移灶表达一种或几种标志物，而其他来源的所有转移灶均为阴性。这种敏感且明显具有特异性的免疫染色在难以确定转移灶乳腺来源的病例中被证明具有很大用途。在4例腋窝淋巴结转移灶中，它甚至导致发现了1例临床和乳腺X线检查均未检测到的隐匿性同侧乳腺癌。本研究表明，联合使用锌-α2-糖蛋白、巨大囊肿病液体蛋白15和雌激素受体是一种有用的免疫染色技术，可帮助病理学家确定乳腺癌转移灶的来源。
