Wallace M L, Longacre T A, Smoller B R
Department of Pathology, Stanford University Medical Center, Stanford, CA, USA.
Mod Pathol. 1995 Dec;8(9):897-901.
Cutaneous metastases of breast carcinoma can be histologically similar to primary skin tumors with eccrine differentiation. We compared the immunohistochemical staining characteristics of 15 metastatic breast carcinoma skin lesions in 12 patients to those of a series of primary eccrine tumors using estrogen receptor, progesterone receptor, and anti-gross cystic disease fluid protein-15 markers. Anti-gross cystic disease fluid protein-15 positivity was noted in 7 of 15 breast carcinoma skin metastases, 0 of 5 benign eccrine tumors, 1 of 6 microcystic adnexal carcinomas, and 1 of 1 metastatic sweat gland adenocarcinoma. Estrogen receptor positivity was found in 1 of 15 metastatic breast carcinoma skin lesions, 0 of 5 benign eccrine tumors, 2 of 8 microcystic adnexal carcinomas, and 1 of 1 metastatic sweat gland adenocarcinoma. Progesterone receptor positivity was identified in 15 of 15 metastatic breast carcinoma skin lesions, 2 of 5 benign eccrine tumors, 5 of 8 microcystic adnexal carcinomas, and 1 of 1 metastatic sweat gland adenocarcinomas. These results indicate that standard immunohistochemical staining for estrogen receptors, progesterone receptors, and gross cystic fluid protein-15 markers will not reliably distinguish primary (or metastatic) eccrine tumors from cutaneous metastases of breast carcinoma.
乳腺癌的皮肤转移在组织学上可能与具有汗腺分化的原发性皮肤肿瘤相似。我们使用雌激素受体、孕激素受体和抗巨大囊肿病液体蛋白-15标记物，比较了12例患者中15个转移性乳腺癌皮肤病变与一系列原发性汗腺肿瘤的免疫组化染色特征。15个乳腺癌皮肤转移灶中有7个抗巨大囊肿病液体蛋白-15呈阳性，5个良性汗腺肿瘤中0个呈阳性，6个微囊性附属器癌中1个呈阳性，1个转移性汗腺腺癌中1个呈阳性。15个转移性乳腺癌皮肤病变中有1个雌激素受体呈阳性，5个良性汗腺肿瘤中0个呈阳性，8个微囊性附属器癌中有2个呈阳性，1个转移性汗腺腺癌中1个呈阳性。15个转移性乳腺癌皮肤病变中有15个孕激素受体呈阳性，5个良性汗腺肿瘤中有2个呈阳性，8个微囊性附属器癌中有5个呈阳性，1个转移性汗腺腺癌中1个呈阳性。这些结果表明，雌激素受体、孕激素受体和巨大囊肿液蛋白-15标记物的标准免疫组化染色不能可靠地将原发性（或转移性）汗腺肿瘤与乳腺癌的皮肤转移区分开来。
