牙囊和星网状层的颗粒蛋白可抑制新生大鼠的牙齿萌出和睁眼。

Granule proteins of the dental follicle and stellate reticulum inhibit tooth eruption and eyelid opening in postnatal rats.

作者信息

Lin F, Fan W, Wise G E

机构信息

Department of Anatomy and Cell Biology, Texas College of Osteopathic Medicine/University of North Texas, Fort Worth 76107-2690.

出版信息

Arch Oral Biol. 1992 Oct;37(10):841-7. doi: 10.1016/0003-9969(92)90118-r.

DOI:10.1016/0003-9969(92)90118-r

PMID:1444894

Abstract

Electron-dense granules within cells of the dental follicle and stellate reticulum of rat mandibular molars can be isolated; their major components are 167 and 200 kDa proteins. Injecting these granule proteins into postnatal rats results in a delay of incisor eruption and eyelid separation. These inhibitory effects were most pronounced with the 167 kDa protein (a delay of 3 days in incisor eruption and of 2 days in eyelid opening) and were opposite to the stimulatory effects of epidermal growth factor. Thus, these granules may play an inhibitory part in tooth eruption.

摘要

大鼠下颌磨牙牙囊和星网状层细胞内的电子致密颗粒能够被分离出来；其主要成分是167 kDa和200 kDa的蛋白质。将这些颗粒蛋白注射到出生后的大鼠体内会导致切牙萌出和眼睑张开延迟。这些抑制作用在167 kDa蛋白中最为明显（切牙萌出延迟3天，眼睑张开延迟2天），并且与表皮生长因子的刺激作用相反。因此，这些颗粒可能在牙齿萌出过程中起抑制作用。