血清抗SS - B/La抗体和IgA类风湿因子是原发性干燥综合征唾液腺疾病活动的标志物。
Serum anti-SS-B/La and IgA rheumatoid factor are markers of salivary gland disease activity in primary Sjögren's syndrome.
作者信息
Atkinson J C, Travis W D, Slocum L, Ebbs W L, Fox P C
机构信息
Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892.
出版信息
Arthritis Rheum. 1992 Nov;35(11):1368-72. doi: 10.1002/art.1780351119.
OBJECTIVE
To identify serologic markers of salivary gland disease activity in 43 patients with primary Sjögren's syndrome.
METHODS
Comparison of salivary gland biopsies (focus scores) and flow rates with serum concentrations of IgA and IgM rheumatoid factor (RF), total serum IgG, serum anti-SS-B/La antibodies, and the erythrocyte sedimentation rate.
RESULTS
Serum anti-SS-B/La antibody levels correlated with focus scores (rs = 0.477, P < 0.0025). Serum IgA-RF concentrations correlated inversely with stimulated parotid gland salivary flow rates (rs = -0.394, P < 0.01).
CONCLUSION
Measuring serum levels of anti-SS-B/La and IgA-RF would be useful when monitoring salivary responses in therapeutic trials, especially in patients with minimal salivary function.
目的
鉴定43例原发性干燥综合征患者唾液腺疾病活动的血清学标志物。
方法
比较唾液腺活检（灶性评分）和流速与血清中IgA和IgM类风湿因子（RF）、总血清IgG、血清抗SS-B/La抗体浓度以及红细胞沉降率。
结果
血清抗SS-B/La抗体水平与灶性评分相关（rs = 0.477，P < 0.0025）。血清IgA-RF浓度与刺激后的腮腺唾液流速呈负相关（rs = -0.394，P < 0.01）。
结论
在治疗试验中监测唾液反应时，检测血清抗SS-B/La和IgA-RF水平将很有用，尤其是对于唾液功能轻微的患者。
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