Scheibe G, Nutzinger D, Buller R, Walther A U
Psychiatric Hospital, University of Munich, Fed. Rep. of Germany.
Arzneimittelforschung. 1992 Sep;42(9):1090-4.
The pretreatment anxiety level is supposed to be a very important unspecific treatment factor. Main purpose of this study is to test whether the patients' pretreatment anxiety level is a general or a specific predictor of treatment response and whether mildly, moderately, and severely anxious patients can be differentially characterized by other diagnostic and clinical variables. 103 patients (37 males, 66 females; mean +/- sd age 35.6 +/- 9.5 years), a subsample of the Second Phase of the Cross-National Collaborative Panic Study, were included in the present study. A high positive correlation of initial anxiousness with the number of panic attacks at the end of treatment was found, moreover high positive correlations with most other baseline assessments. Initially severely anxious patients are the severest ill patients with the least treatment response, and that in all treatment groups. The pretreatment anxiety level predicts the number of panic attacks as well as the degree of avoidance behavior in both drug groups, whereas it predicts anticipatory anxiety intensity in the placebo group.
治疗前焦虑水平被认为是一个非常重要的非特异性治疗因素。本研究的主要目的是测试患者的治疗前焦虑水平是治疗反应的一般预测因素还是特定预测因素，以及轻度、中度和重度焦虑患者是否可以通过其他诊断和临床变量进行差异特征描述。本研究纳入了103名患者（37名男性，66名女性；平均年龄±标准差为35.6±9.5岁），他们是跨国协作惊恐研究第二阶段的一个子样本。研究发现，初始焦虑程度与治疗结束时的惊恐发作次数呈高度正相关，此外，与大多数其他基线评估也呈高度正相关。最初严重焦虑的患者是病情最严重且治疗反应最差的患者，在所有治疗组中都是如此。治疗前焦虑水平可预测两个药物组中的惊恐发作次数以及回避行为程度，而在安慰剂组中，它可预测预期焦虑强度。
