Yoshimura Y, Miyaoka H, Ota A, Tatsumi M, Sakai T, Nozaki S, Kinami Y, Kamijima K
Department of Psychiatry, Showa University School of Medicine.
Seishin Shinkeigaku Zasshi. 1996;98(9):667-79.
In this study we investigated the one-year outcome of panic disorder. The subjects were 169 panic disorder patients (69 males, 100 females; mean age 36.5 years), who attended the outpatient clinic of the Department of Psychiatry, Showa University Hospital, from September to December 1993. The outcome study was performed from October to December 1994. Patients who were being treated at Showa University Hospital during the outcome study were interviewed in person, and those who were not were interviewed by telephone. The one-year outcome of 100 patients (32 interviewed in person and 68 interviewed by telephone; 37 males, 63 females; mean age 39.5 years) was assessed. That of the remaining 69 patients was not assessed because they did not provide informed consent or had moved during the last year. The patients who were assessed (N = 100) were older and exhibited less severe phobic avoidance on their first visit to the clinic than those who were not assessed (N = 69). The frequency of panic attacks, and the severity of phobic avoidance and anticipatory anxiety decreased significantly between the time of the patients' first visit to the clinic and the time of the outcome study. Panic attacks, phobic avoidance and anticipatory anxiety disappeared in 27.0%, 32.9% and 13.6% and decreased in frequency or severity in 61.8%, 62.0% and 61.4% of the cases, respectively. Seventy-three patients felt that the severity of their panic disorder symptoms decreased between the time of the outcome study and the time of their first visit to the clinic, 20 felt that it had not changed and 7 felt that it had increased worse. The phobic avoidance and anticipatory anxiety at the time of the patients' first visit to the clinic were more severe, and the Global Assessment of Functioning Scale score was lower in the case of the former group of patients than in that of the latter two groups.
在本研究中，我们调查了惊恐障碍的一年期转归情况。研究对象为169例惊恐障碍患者（男性69例，女性100例；平均年龄36.5岁），他们于1993年9月至12月在昭和大学医院精神科门诊就诊。转归研究于1994年10月至12月进行。在转归研究期间仍在昭和大学医院接受治疗的患者接受了面对面访谈，未在该院治疗的患者则通过电话进行访谈。对100例患者（32例面对面访谈，68例电话访谈；男性37例，女性63例；平均年龄39.5岁）的一年期转归进行了评估。其余69例患者的转归未作评估，因为他们未提供知情同意或在过去一年中搬走了。接受评估的患者（N = 100）比未接受评估的患者（N = 69）年龄更大，且首次就诊时的恐惧回避症状较轻。在患者首次就诊至转归研究期间，惊恐发作的频率、恐惧回避及预期焦虑的严重程度均显著下降。惊恐发作、恐惧回避和预期焦虑分别在27.0%、32.9%和13.6%的病例中消失，在61.8%、62.0%和61.4%的病例中发作频率或严重程度降低。73例患者感觉其惊恐障碍症状的严重程度在转归研究时较首次就诊时有所减轻，20例感觉未变，7例感觉加重。前一组患者首次就诊时的恐惧回避和预期焦虑更严重，且功能总体评定量表评分低于后两组患者。
