某些药物对离体蟾蜍脊髓背根电位的作用。
Action of some drugs on the dorsal root potentials of the isolated toad spinal cord.
作者信息
KIRALY J K, PHILLIS J W
出版信息
Br J Pharmacol Chemother. 1961 Oct;17(2):224-31. doi: 10.1111/j.1476-5381.1961.tb01282.x.
Abstract
A series of drugs which potentiate or antagonize transmission at cholinergic synapses have been tested on the slow depolarizing dorsal root potentials evoked by stimulation of adjacent dorsal and ventral roots. Some drugs acted specifically on the dorsal root potential evoked by ventral root stimulation. Dihydro-beta-erythroidine, atropine and acetylcholine depressed this potential, whilst anticholinesterase substances in low concentrations potentiated and in higher concentrations depressed it. It is concluded that the results offer some evidence for a cholinergic link in the pathway responsible for the generation of depolarizing potentials in the dorsal root subsequent to ventral root stimulation.
摘要
一系列增强或拮抗胆碱能突触传递的药物，已针对刺激相邻背根和腹根所诱发的缓慢去极化背根电位进行了测试。一些药物特异性作用于腹根刺激所诱发的背根电位。二氢-β-刺桐定、阿托品和乙酰胆碱可抑制该电位，而低浓度的抗胆碱酯酶物质可增强该电位，高浓度时则抑制它。得出的结论是，这些结果为腹根刺激后在背根中产生去极化电位的通路中存在胆碱能联系提供了一些证据。
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