被破坏的鼠类肿瘤病毒对淋巴细胞转化的抑制作用。
Inhibition of lymphocyte transformation by disrupted murine oncornavirus.
作者信息
Fowler A K, Twardzik D R, Reed C D, Weislow O S, Hellman A
出版信息
Cancer Res. 1977 Dec;37(12):4529-31.
PMID:144563
Abstract
Freeze-thaw preparations of banded Rauscher murine leukemia virus markedly suppressed the in vitro cellular-mediated blastogenic response of murine splenic lymphocytes to phytohemagglutinin-P and to allogeneic cells in two-way mixed-leukocyte reaction. Suppression was shown not to be due to cytotoxicity or to virus-mitogen binding. It is suggested that a virion envelope component interferes with cellular-mediated immunity by altering cell recognition sites.
摘要
带状劳氏鼠白血病病毒的冻融制剂在体外显著抑制了鼠脾淋巴细胞对植物血凝素-P以及在双向混合淋巴细胞反应中对同种异体细胞的细胞介导的增殖反应。抑制作用并非由细胞毒性或病毒与促细胞分裂剂的结合所致。有人提出，病毒粒子包膜成分通过改变细胞识别位点来干扰细胞介导的免疫。
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