Schumacher H, Nir M, Mansa B, Grassy A
Department of Hospital Infections and Antibiotics, Statens Seruminstitut, Copenhagen, Denmark.
APMIS. 1992 Oct;100(10):954-6.
The occurrence of resistance and production of beta-lactamases was investigated in 60 Shigella strains. Ampicillin resistance was found in 28 (47%) of the isolates, the resistance being more frequent in Sh. flexneri than in Sh. sonnei. All strains were susceptible to cefotaxime, mecillinam, and ciprofloxacin. The beta-lactamases produced by Shigella were similar to TEM-1, OXA-1, or the low-level chromosomally mediated cephalosporinase produced by Escherichia coli. The beta-lactamases produced by Sh. flexneri were most often the OXA-1-like enzymes.
对60株志贺氏菌菌株进行了耐药性及β-内酰胺酶产生情况的研究。在28株（47%）分离菌株中发现了氨苄西林耐药性，弗氏志贺氏菌中的耐药性比宋内志贺氏菌更为常见。所有菌株对头孢噻肟、美西林和环丙沙星均敏感。志贺氏菌产生的β-内酰胺酶与TEM-1、OXA-1或大肠杆菌产生的低水平染色体介导的头孢菌素酶相似。弗氏志贺氏菌产生的β-内酰胺酶最常为OXA-1样酶。
