Krapivin S V, Sergeeva S A
Biull Eksp Biol Med. 1992 Jun;113(6):619-21.
The influence of nomifensine on bioelectrical activity of sensorimotor cortex, dorsal hippocamp and lateral hypothalamus in conscious rats in free behavior was studied. The pharmacological and EEG analysis of nomifensine action on EEG power spectra by Fourier technique was measured. It was established that nomifensine evoked an increase and stabilization of the dominant peak in EEG spectra in the left and right cortex and in the left hippocamp, while in the other ranges of frequency a decrease was observed. The effects on hypothalamus was opposite--EEG power spectra decreased in all the ranges. The authors conclude that nomifensine evokes higher level of wakefulness, vigilance of the animals. This is likely to underlie neurophysiological mechanisms of optimal behavior due to stimulants of CNS, including nomifensine.
研究了去甲丙咪嗪对自由行为的清醒大鼠感觉运动皮层、背侧海马和外侧下丘脑生物电活动的影响。采用傅里叶技术对去甲丙咪嗪作用于脑电图功率谱的药理作用和脑电图进行了分析测定。结果表明，去甲丙咪嗪可使左右皮层及左侧海马脑电图谱中的主峰升高并稳定，而在其他频率范围内则出现降低。对下丘脑的影响则相反——所有频率范围内脑电图功率谱均降低。作者得出结论，去甲丙咪嗪可使动物的觉醒水平和警觉性提高。这可能是包括去甲丙咪嗪在内的中枢神经系统兴奋剂产生最佳行为的神经生理机制基础。
