Krapivin S V, Sergeeva S A, Morozov I S
Eksp Klin Farmakol. 1992 May-Jun;55(3):6-8.
A study was made of the influence of adapromine on bioelectrical activity of the brain, sensorimotor cortex, dorsal hippocamp and lateral hypothalamus in freely moving wakeful rats. Adapromine was established to evoke a decrease of the amplitude of the dominant peak and dominant theta-activity in power spectra of the EEG in the cortex and hippocamp, with an increase of rapid wave activity in the beta 2 range in the right cortex and hippocamp. These changes attained maximum after 1 to 1.5 hour and lasted up to 4-5 hours after adapromine administration. These changes can be viewed as activation of the cortex and hippocamp, which may attest to the presence of antidepressive and psychostimulant effects in the action spectrum of adapromine. The specific influence of adapromine on catecholaminergic processes of the brain may lie at the basis of the above effects.
研究了阿地普明对自由活动的清醒大鼠大脑、感觉运动皮层、背侧海马体和外侧下丘脑生物电活动的影响。已证实阿地普明可使皮层和海马体脑电图功率谱中主峰和优势θ活动的振幅降低，同时右侧皮层和海马体中β2范围内的快波活动增加。这些变化在给药后1至1.5小时达到最大值，并在给药后持续4至5小时。这些变化可视为皮层和海马体的激活，这可能证明阿地普明的作用谱中存在抗抑郁和精神兴奋作用。阿地普明对大脑儿茶酚胺能过程的特定影响可能是上述作用的基础。
