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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Williams R R, Hunt S C, Hopkins P N, Wu L L, Schumacher M C, Stults B M, Ball L, Ware J, Hasstedt S J, Lalouel J M

University of Utah Cardiovascular Genetics Research Clinic, Department of Internal Medicine, Salt Lake City.

Clin Exp Pharmacol Physiol Suppl. 1992;20:1-6.

Among 45,258 Utah families surveyed, about 4% have a strong aggregation of early coronary disease. In detailed clinical evaluation, about 21% of such high risk coronary families were found to have familial dyslipidaemic hypertension (FDH) and about 3% were found to have heterozygous familial hypercholesterolaemia (hFH). 2. Common and potentially modifiable environmental factors seem to play an important role in these high risk families. Non-genetic obesity promotes the expression of FDH. A high fat diet promotes the expression of FH. Cigarette smoking promotes earlier death in all coronary prone families. 3. Practical approaches are suggested for helping coronary prone pedigrees by applying our understanding of genetic and environmental factors that promote earlier coronary disease onset.

在接受调查的45258个犹他州家庭中，约4%有早期冠心病的强烈聚集现象。在详细的临床评估中，约21%的此类高危冠心病家庭被发现患有家族性血脂异常性高血压（FDH），约3%被发现患有杂合子家族性高胆固醇血症（hFH）。2. 常见且可能可改变的环境因素似乎在这些高危家庭中起重要作用。非遗传性肥胖促进FDH的表达。高脂肪饮食促进FH的表达。吸烟会促使所有易患冠心病的家庭更早死亡。3. 根据我们对促进冠心病更早发病的遗传和环境因素的理解，提出了帮助易患冠心病家系的实用方法。

Williams R R, Hunt S C, Hopkins P N, Wu L L, Schumacher M C, Stults B M, Ball L, Ware J, Hasstedt S J, Lalouel J M

University of Utah Cardiovascular Genetics Research Clinic, Department of Internal Medicine, Salt Lake City.

Clin Exp Pharmacol Physiol Suppl. 1992;20:1-6.

Among 45,258 Utah families surveyed, about 4% have a strong aggregation of early coronary disease. In detailed clinical evaluation, about 21% of such high risk coronary families were found to have familial dyslipidaemic hypertension (FDH) and about 3% were found to have heterozygous familial hypercholesterolaemia (hFH). 2. Common and potentially modifiable environmental factors seem to play an important role in these high risk families. Non-genetic obesity promotes the expression of FDH. A high fat diet promotes the expression of FH. Cigarette smoking promotes earlier death in all coronary prone families. 3. Practical approaches are suggested for helping coronary prone pedigrees by applying our understanding of genetic and environmental factors that promote earlier coronary disease onset.

在接受调查的45258个犹他州家庭中，约4%有早期冠心病的强烈聚集现象。在详细的临床评估中，约21%的此类高危冠心病家庭被发现患有家族性血脂异常性高血压（FDH），约3%被发现患有杂合子家族性高胆固醇血症（hFH）。2. 常见且可能可改变的环境因素似乎在这些高危家庭中起重要作用。非遗传性肥胖促进FDH的表达。高脂肪饮食促进FH的表达。吸烟会促使所有易患冠心病的家庭更早死亡。3. 根据我们对促进冠心病更早发病的遗传和环境因素的理解，提出了帮助易患冠心病家系的实用方法。