Slack J
Postgrad Med J. 1975;51(8):suppl 27-32.
Many factors both genetic and environmental contribute to the liability to coronary heart disease and one of the genetically determined risk factors is the concentration of lipoproteins in the blood. The evidence so far is that serum cholesterol level is polygenically determined, but that in a minority of the population it is determined by a single mutant gene of large effect. There is evidence that the risk of coronary death for affected individuals is very high and that the condition warrants a maximum effort at identification and treatment. For the remainder of the population whose hyperlipidaemia is polygenically determined, the liability to coronary heart disease might be substantially reduced by simple and appropriate environmental measures aimed at reducing the total liability. The measures if correctly applied should effectively improve the population risks of early coronary death.
许多遗传和环境因素都与冠心病易感性有关，而血液中脂蛋白浓度是由遗传决定的风险因素之一。目前的证据表明，血清胆固醇水平是由多个基因决定的，但在少数人群中，它是由一个具有较大效应的单基因突变决定的。有证据表明，受影响个体的冠状动脉死亡风险非常高，这种情况值得尽最大努力进行识别和治疗。对于其余高脂血症由多个基因决定的人群，通过旨在降低总体易感性的简单而适当的环境措施，可能会大幅降低冠心病易感性。如果正确应用这些措施，应该能有效降低人群早期冠状动脉死亡的风险。
